Endocrine Abstracts

What do we mean by ‘osteoporosis’? Essentially, bone of reduced mass that is abnormal at a micro-architectural level, with an increased propensity to fracture. The detection of such abnormality is not straight-forward. Any bone will fracture given sufficient force, and it might be thought that restricting further investigation to those who fracture following mild or trivial trauma would be the way forward. Defining what level of trauma should be regarded as ‘mil...

Introduction: We have recently presented data demonstrating total body and regional bone mass relative to body size is reduced in obese children. Adipokines have been shown to play a role in bone metabolism. We hypothesised that 1) increased bone turnover would be associated with reduced bone mass 2) increased serum leptin would be associated with increased osteoclastogenic factors 3) reduced adiponectin woul...

We have previously shown that obese children with prior fracture have a lower bone mass for body size. We further hypothesised that obese children would fail to gain bone mass in relation to body size over a one-year period compared to lean controls.Methodology: Out of 103 children recruited into obese (BMI>98th percentile) and control (BMI<98th percentile) groups at baseline, 66 children aged 6.5–18 years returned at one year. Total body an...